Introduction

• DNA and RNA are biological macromolecules called nucleic acids. Nucleic acids play important roles in conveying and expressing genetic information. Our laboratory (Department of Nucleic Acids Biochemistry) conducts various original studies related to genetic information using nucleic acids. We are trying to improve understanding of mutagenesis and carcinogenesis mechanisms by damaged nucleic acids and overcome disorders, including cancers, by gene therapy.

News新着情報

2024.10.09

The article entitled ''Escherichia coli Orf135 (NudG) Mutant Protein Specific for Oxidized dATP'' was accepted by Nucleosides Nucleotides Nucleic Acids.

2024.10.01

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2024.09.24

The article entitled ''Split MutT prevents the mutator phenotype of mutT-deficient Escherichia coli'' was accepted by Genes and Environment.

2024.05.29

The article entitled ''Inhibition of uracil DNA glycosylase alters frequency and spectrum of action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine'' was accepted by Biological and Pharmaceutical Bulletin.

2024.04.20

The article entitled ''Visualization of oxidized guanine nucleotides accumulation in living cells with split MutT'' was accepted by Nucleic Acids Research.

2024.04.01

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2023.12.18

The article entitled ''Correction of substitution, deletion, and insertion mutations by 5'-tailed duplexes'' was accepted by Journal of Bioscience and Bioengineering.

2023.10.02

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2023.07.12

The article entitled ''Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3'' was accepted by Mutagenesis.

2023.04.03

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2022.10.25

The article entitled ''Easily-controllable, helper phage-free single-stranded phagemid production system'' was accepted by Genes & Environment.

2022.10.04

The article entitled ''Development of a versatile high-throughput mutagenesis assay with multiplexed short read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli'' was accepted by eLife.

2022.10.01

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2022.08.09

The article entitled ''Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine'' was accepted by Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.

2022.06.25

The article entitled ''Correction of monomeric enhanced green fluorescent protein (mEGFP) gene by short 5'-tailed duplexes'' was accepted by Journal of Bioscience and Bioengineering.

2022.04.01

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2022.01.20

The article entitled ''Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine'' was accepted by DNA Repair.

2021.10.06

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2021.08.25

The article entitled ''Gene correction by 5'-tailed duplexes with short editor oligodeoxyribonucleotides'' was accepted by Journal of Bioscience and Bioengineering.

2021.07.15

The article entitled ''Action-at-a-distance mutations at 5'-GpA-3' sites by oxidized guanine in WRN-knockdown cells'' was accepted by Mutagenesis.

2021.04.07

The article entitled ''Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions'' was accepted by Journal of Toxicological Sciences.

2021.04.01

Dr. Yoshihiro Fujikawa took office as an assistant professor.

2021.04.01

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2020.10.01

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2020.09.14

The article entitled ''New indicator Escherichia coli strain for rapid and accurate detection of supF mutations'' was accepted by Genes & Environment.

2020.05.27

The article entitled ''Single-stranded DNA versus tailed duplex in sequence conversion of lacZα DNA'' was accepted by Nucleosides Nucleotides and Nucleic Acids.

2020.04.01

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2019.12.13

The article entitled ''High-throughput analysis of DNA repair in microplates towards identification of inhibitors'' was accepted by Genes & Environment.

2019.10.29

The article entitled ''Conventional plasmid DNAs with a CpG-containing backbone achieve durable transgene expression in mouse liver'' was accepted by Journal of Gene Medicine.

2019.10.09

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2019.09.24

The article entitled ''Large deletions and untargeted substitutions induced by abasic site analog on leading versus lagging strand templates in human cells'' was accepted by Mutagenesis.

2019.06.25

The article entitled ''No enhancing effects of plasmid-specific histone acetyltransferase recruitment system on transgene expression in vivo'' was accepted by Nucleosides Nucleotides and Nucleic Acids.

2019.04.01

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2018.10.01

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2018.09.18

The article entitled ''Analysis of large deletion mutations induced by abasic site analog in human cells'' was accepted by Genes & Environment.

2018.08.05

The article entitled ''Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase λ-double knockdown cells'' was accepted by Mutagenesis.

2018.07.02

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2018.06.26

The article entitled ''Durable transgene expression driven by CpG-free and -containing promoters in plasmid DNA with CpG-free backbone'' was accepted by Biological and Pharmaceutical Bulletin.

2018.04.05

The article entitled ''Reduction of Werner syndrome protein enhances G:C → A:T transition by O⁶-methylguanine in human cells'' was accepted by Chemical Research in Toxicology.

2018.04.02

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2017.12.20

The article entitled ''Effects of mismatches distant from the target position on gene correction with a 5'-tailed duplex'' was accepted by Journal of Bioscience and Bioengineering.

2017.10.06

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2017.09.01

Dr. Hidehiko Kawai took office as an associate professor.

2017.02.23

The article entitled ''Comparison of DNA fragments as donor DNAs upon sequence convesion of cleaved target DNA'' was accepted by Nucleosides Nucleotides and Nucleic Acids.

2017.02.23

The article entitled ''DNA polymerase κ protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis'' was published by Genes & Environment.

2016.10.04

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2016.09.15

The article entitled ''Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase'' was accepted by Journal of Bioscience and Bioengineering.

2016.09.15

The article entitled ''Mutator phenotype and DNA double-strand break repair in BLM helicase-deficient human cells'' was accepted by Molecular and Cellular Biology.

2016.09.15

The article entitled ''The role of DNA polymerase ζ in translesion synthesis across bulky DNA adducts and cross-links human cells'' was accepted by Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.

2016.06.13

The review article entitled ''Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells.'' was accepted by Genes & Environment.

2016.06.13

The article entitled ''Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase ζ to genotoxic stresses.'' was accepted by DNA Repair.

2016.05.14

The article entitled ''Cleavage of target DNA promotes sequecne conversion with a tailed duplex.'' was accepted by Biological and Pharmaceutical Bulletin.

2016.04.27

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2016.03.09

English website was established.