2024年 2023年 2022年 2021年 2020年 2019年 2018年 2017年 2016年 2015年 2014年 2013年 2012年 2011年
2024年
原著論文
1. Kamiya H.
Escherichia coli Orf135 (NudG) Mutant Protein Specific for Oxidized dATP.
Nucleosides, Nucleotides Nucleic Acids, in press
2. Kamiya H.
Split MutT prevents the mutator phenotype of mutT-deficient Escherichia coli.
Genes Environment, 46, 19 (6 pages) (2024)
3. Hernandez A, Hedlich-Dwyer J, Hussain S, Levi H, Sonavane M, Suzuki
T, Kamiya H and Gassman NR.
Acute exposure to dihydroxyacetone promotes genotoxicity and chromosomal
instability in lung, cardiac, and liver cell models.
Toxicol. Sci., 201, 85-102 (2024)
4. Suzuki T, Yoshida S and Kamiya H.
Inhibition of uracil DNA glycosylase alters frequency and spectrum of action-at-a-distance
mutations induced by 8-oxo-7,8-dihydroguanine.
Biol. Pharm. Bull., 47, 1275-1281 (2024)
5. Fujikawa Y, Kawai H, Suzuki T and Kamiya H.
Visualization of oxidized guanine nucleotides accumulation in living cells with split MutT.
Nucleic Acids Res., 52, 6532-6542 (2024) (プレスリリース：https://www.hiroshima-u.ac.jp/news/83160)
6. Kawai H, Sato K, Kato T and Kamiya H.
Correction of substitution, deletion, and insertion mutations by 5'-tailed duplexes.
J. Biosci. Bioeng., 137, 157-164 (2024)
7. Fukushima R, Suzuki T, Kobayakawa A and Kamiya H.
Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are
dependent on APOBEC3.
Mutagenesis, 39, 24-31 (2024)
2022年
原著論文
1. Suzuki T and Kamiya H.
Easily-controllable, helper phage-free single-stranded phagemid production
system.
Genes Environment, 44, 25 (8 pages) (2022)
2. Shinriki S, Hirayama M, Nagamachi A, Yokoyama A, Kawamura T, Kanai A, Kawai H, Iwakiri J, Liu R, Maeshiro M, Tungalag S, Tasaki M, Ueda M, Tomizawa K, Kataoka N, Ideue T, Suzuki Y, Asai K, Tani T, Inaba T and Matsui H.
DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells.
Leukemia, 36, 2605-2620 (2022)
3. Kawai H, Iwata R, Ebi S, Sugihara R, Masuda S, Fujiwara C, Kimura S and
Kamiya H.
Development of a versatile high-throughput mutagenesis assay with multiplexed
short read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli.
eLife, 11, e83780 (2022) (プレスリリース：https://www.hiroshima-u.ac.jp/news/73806)
4. Fukushima R, Suzuki T, Komatsu Y and Kamiya H.
Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine.
Mutat. Res./Fund. Mol. Mech., 825, 111794 (2022)
5. Kawai H, Kamitsubo R and Kamiya H.
Correction of monomeric enhanced green fluorescent protein (mEGFP) gene by short 5'-tailed duplexes.
J. Biosci. Bioeng., 134, 175-181 (2022)
6. Kanao R, Kawai H, Taniguchi T, Takata M and Masutani C.
RFWD3 and translesion DNA polymerases contribute to PCNA modification-dependent DNA damage tolerance.
Life Sci. Alliance, 5, e202201584 (2022)
7. Suzuki T, Zaima Y, Fujikawa Y, Fukushima R and Kamiya H.
Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine.
DNA Repair, 111, 103276 (2022) (プレスリリース：https://www.hiroshima-u.ac.jp/news/69162)
2021年
原著論文
1. Kawai H, Yazama K, Yanai Y, Kamitsubo R and Kamiya H.
Gene correction by 5'-tailed duplexes with short editor oligodeoxyribonucleotides.
J. Biosci. Bioeng., 132, 552-559 (2021)
2. Suzuki T, Masuda H, Mori M, Ito R and Kamiya H.
Action-at-a-distance mutations at 5'-GpA-3' sites induced by oxidized guanine
in WRN-knockdown cells.
Mutagenesis, 36, 349-357 (2021)
3. Suzuki T, Katayama Y, Komatsu Y and Kamiya H.
Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions.
J. Toxicol. Sci., 46, 283-288 (2021)
4. Suzuki T, Sassa A, Grúz P, Gupta RC, Johnson F, Adachi N and Nohmi
T.
Error-prone bypass patch by a low-fidelity variant of DNA polymerase ζ in human cells.
DNA Repair, 100, 103052 (2021)
2020年
原著論文
1. Takeishi A, Kogashi H, Odagiri M, Sasanuma H, Takeda S, Yasui M, Honma M, Suzuki T, Kamiya H, Sugasawa K, Ura K and Sassa A.
Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide
embedded into DNA in human cells.
PLoS ONE, 15, e0244790 (2020)
2. Fukushima R, Suzuki T and Kamiya H.
New indicator Escherichia coli strain for rapid and accurate detection of supF mutations.
Genes Environment, 42, 28 (9 pages) (2020)
3. Kawai H, Sato K, Shirahama W, Suzuki T and Kamiya H.
Single-stranded DNA versus tailed duplex in sequence conversion of lacZα
DNA.
Nucleosides, Nucleotides Nucleic Acids, 39, 1245-1250 (2020)
4. Suzuki T, Wakao Y, Goda T and Kamiya H.
Conventional plasmid DNAs with a CpG-containing backbone achieve durable
transgene expression in mouse liver.
J. Gene Med., 22, e3138 (6 pages) (2020)
5. Suzuki T, Miura N, Hojo R, Yanagiba Y, Suda M, Hasegawa T, Miyagawa M and
Wang RS.
Genotoxicity assessment of titanium dioxide nanoparticle accumulation of
90 days in the liver of gpt delta transgenic mice.
Genes Environment, 42, 7 (6 pages) (2020)
その他
1. Kamiya H.
High-throughput analysis of DNA repair in microplates towards identification
of inhibitors.
Genes Environment, 42, 11 (3 pages) (2020)
2019年
原著論文
1. Suzuki T, Katayama Y, Komatsu Y and Kamiya H.
Large deletions and untargeted substitutions induced by abasic site analog
on leading versus lagging strand templates in human cells.
Mutagenesis, 34, 421-429 (2019)
2. Suzuki T, Wakao Y, Watanabe T, Hori M, Ikeda Y, Tsuchiya H, Kogure K, Harada-Shiba
M, Fujimuro M and Kamiya H.
No enhancing effects of plasmid-specific histone acetyltransferase recruitment system on transgene expression in vivo.
Nucleosides, Nucleotides Nucleic Acids, 38, 942-949 (2019)
3. Ueda M, Matsuura K, Kawai H, Wakasugi M and Matsunaga T.
Spironolactone-induced XPB degradation depends on CDK7 kinase and SCFFBXL18 E3 ligase.
Genes Cells, 24, 284-296 (2019)
4. Masuda Y, Kanao R, Kawai H, Kukimoto I and Masutani C.
Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates.
J. Biol. Chem., 294, 4177-4187 (2019)
2018年
原著論文
1. Suzuki T, Katayama Y, Komatsu Y and Kamiya H.
Analysis of large deletion mutations induced by abasic site analog in human
cells.
Genes Environment, 40, 24 (8 pages) (2018)
2.
Kamiya H, Makino T, Suzuki T, Kobayashi M and Matsuoka I.
Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase λ-double knockdown cells.
Mutagenesis, 33, 301-310 (2018)
3.
Suzuki T, Goda T and Kamiya H.
Durable transgene expression driven by CpG-free and -containing promoters
in plasmid DNA with CpG-free backbone.
Biol. Pharm. Bull., 41, 1489-1493 (2018)
4.
Suzuki T, Kuramoto Y and Kamiya H.
Reduction of Werner syndrome protein enhances G:C → A:T transition by O6-methylguanine in human cells.
Chem. Res. Toxicol., 31, 319-324 (2018)
5.
Suzuki T, Yanai Y, Nishigaki N, Nakatsu Y, Tsuzuki T and Kamiya H.
Effects of mismatches distant from the target position on gene correction
with a 5'-tailed duplex.
J. Biosci. Bioeng., 125, 619-623 (2018)
6.
Suzuki T, Matsumoto K, Honma M and Nohmi T.
Impact of DNA polymerase ζ mutations on genotoxic thresholds of oxidative mutagens.
Mutat. Res./Gen. Tox. En., 828, 10-14 (2018)
7.
Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K and Kunugita
N.
Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS-Activated TGFβ Signaling.
Mol. Cancer Res., 16, 1676-1686 (2018)
8.
Okamoto Y, Iwasaki WM, Kugou K, Takahashi KK, Oda A, Sato K, Kobayashi
W, Kawai H, Sakasai R, Takaori-Kondo A, Yamamoto T, Kanemaki MT, Taoka
M, Isobe T, Kurumizaka H, Innan H, Ohta K, Ishiai M and Takata M.
Replication stress induces accumulation of FANCD2 at central region of large fragile genes.
Nucleic Acids Res., 46, 2932-2944 (2018)
2017年
総説論文
1.
Suzuki T and Kamiya H.
Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative
oxidized base, in mammalian cells.
Genes Environment, 39, 2 (6 pages) (2017)
原著論文
1.
Suzuki T, Imada T, Komatsu Y and Kamiya H.
Comparison of DNA fragments as donor DNAs upon sequence convesion of cleaved
target DNA.
Nucleosides Nucleotides Nucleic Acids, 36, 428-434 (2017)
2.
Nishihara M, Kanda GN, Suzuki T, Yamakado S, Harashima H and Kamiya H.
Enhanced transgene expression by plasmid-specific recruitment of histone
acetyltransferase.
J. Biosci. Bioeng., 123, 277-280 (2017)
3.
Kanemaru Y, Suzuki T, Sassa A, Matsumoto K, Adachi N, Honma M, Numazawa
S and Nohmi T.
DNA polymerase κ protects human cells against MMC-induced genotoxicity
through error-free translesion DNA synthesis.
Genes Environment, 39, 6 (10 pages) (2017)
4.
Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K and Kunugita
N.
ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts.
Cell Cycle, 16, 2345-2354 (2017)
2016年
原著論文
1.
Suzuki T, Yasui M and Honma M.
Mutator phenotype and DNA double-strand break repair in BLM helicase-deficient
human cells.
Mol. Cell. Biol., 36, 2877-2889 (2016)
2.
Suzuki T, Grúz P, Honma M, Adachi N and Nohmi T.
The role of DNA polymerase ζ in translesion DNA synthesis across bulky
DNA adducts and cross-links in human cells.
Mutat. Res., 791-792, 35-41 (2016)
3.
Suzuki T, Grúz P, Honma M, Adachi N and Nohmi T.
Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity
variants of DNA polymerase ζ to genotoxic stresses.
DNA Repair, 45, 34-43 (2016)
4.
Suzuki T, Imada T, Nishigaki N, Kobayashi M, Matsuoka I and Kamiya H.
Cleavage of target DNA promotes sequence conversion with a tailed duplex
Biol. Pharm. Bull., 39, 1392-1395 (2016)
5.
Kamiya H, Ito M, Nishi K and Harashima H.
In vivo selection of active deoxyribonucleotide kinase by a mutagenic nucleoside
analog.
J. Biotechnol., 228, 52-57 (2016)
6.
Suzuki T, Miura N, Hojo R, Yanagiba Y, Suda M, Hasegawa T, Miyagawa M and
Wang RS.
Genotoxicity assessment of intravenously injected titanium dioxide nanoparticles in gpt delta transgenic mice
Mutat. Res., 802, 30-37 (2016)
7.
Kamiya H, Nishigaki N, Ikeda A, Yukawa S, Morita Y, Nakatsu Y, Tsuzuki
T and Harashima H.
Insertion and deletion mismatches distant from the target position improve
gene correction with a tailed duplex
Nucleosides Nucleotides Nucleic Acids, 35, 379-388 (2016)
2015年
原著論文
1.
Kamiya H, Kurokawa M, Makino T, Kobayashi M and Matsuoka I.
Induction of action-at-a-distance mutagenesis by 8-oxo-7,8-dihydroguanine
in DNA pol λ-knockdown cells.
2.
Kanemaru Y, Suzuki T, Niimi N, Grúz P, Matsumoto K, Adachi N, Honma M and
Nohmi T.
Catalytic and non-catalytic roles of DNA polymerase κ in protection of
human cells against genotoxic stresses.
Environ. Mol. Mutagen., 56, 650-662 (2015)
3. Yanagiba Y, Suzuki T, Suda M,
Hojo R, Gonzalez FJ, Nakajima T and Wang RS.
Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage.
Toxicol. Ind. Health, 0748233714568801 (OnlineFirst) (2015)
4.
Kamiya H, Yamazaki D, Nakamura
E, Makino T, Kobayashi M, Matsuoka I and Harashima H.
Action-at-a-Distance Mutagenesis Induced by Oxidized Guanine in Werner
Syndrome Protein-Reduced Human Cells.
Chem. Res. Toxicol., 28, 621-628 (2015)
5.
Maruyama H, Furukawa K, Kamiya H,
Minakawa N and Matsuda A.
Transcription of 4'-thioDNA templates to natural RNA in vitro and in mammalian
cells.
Chem. Commun., 51, 7887-7890 (2015)
2014年
原著論文
1.
Kanda GN, Miyamoto S, Kobayashi
M, Matsuoka I, Harashima H and Kamiya H.
Anatomy of plasmid DNAs with anti-silencing elements.
Int. J. Pharm., 464, 27-33 (2014)
2.
Kamiya H, Suzuki T and Harashima
H.
Suppression of Short Tract Gene Conversion in Episomal DNA by p53 Reduction.
Genes Environment, 35, 65-68 (2014)
3.
Suzuki T, Yanagiba Y, Suda M,
Wang RS.
Assessment of the Genotoxicity of 1,2-Dichloropropane and
Dichloromethane after Individual and Co-exposure by Inhalation in Mice.
J. Occup. Health, 56, 205-214 (2014)
4.
Miura
N, Ohtani K, Hasegawa T, Hojo R, Yanagiba Y, Suzuki T, Suda M, Wang RS.
Hazardous effects of titanium dioxide nanoparticles on testicular
function in mice.
Fund. Toxicol. Sci., 1, 81-85 (2014)
5.
Sassa A, Suzuki T, Kanemaru Y,
Niimi N, Fujimoto H, Katafuchi A, Grúz P, Yasui M, Gupta RC, Johnson F, Ohta T,
Honma M, Adachi N and Nohmi T.
In vivo evidence that phenylalanine 171 acts as a molecular brake
for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA
polymerase kappa.
DNA Repair, 15, 21-28 (2014)
6.
Yasui M, Kanemaru Y, Kamoshita N,
Suzuki T, Arakawa T and Honma M.
Tracing the fates of site-specifically introduced DNA adducts in the
human genome.
DNA Repair, 15, 11-20 (2014)
2013年
原著論文
1.
Iida S, Kamiya H, Nakaya A,
Hayashi Y, Sawada A, Kaji N, Baba Y and Harashima H.
Reduced plasma glucose by asparagine synthetase knockdown in the mouse
liver.
Biol. Pharm. Bull., 36, 2009-2011 (2013)
2.
Kamiya H and Kurokawa M.
DNA polymerase λ promotes mutagenesis induced by 8-oxo-7,8-dihydroguanine
(8-hydroxyguanine) paired with adenine.
Genes Environment, 35, 105-109 (2013)
3.
Togashi R, Harashima H and
Kamiya H.
Correlation between transgen expression and plasmid DNA loss in mouse liver.
J. Gene. Med., 15, 242-248 (2013)
4.
Kamiya H, Miyamoto S, Goto H,
Kanda GN, Kobayashi M, Matsuoka I and Harashima H.
Enhanced transgene expression from chromatinized plasmid DNA in
mouse liver.
Int. J. Pharm., 441, 146-150 (2013)
5.
Suzuki T, Ukai A, Honma M,
Adachi N and Nohmi T.
Restoration of mismatch repair functions in human cell line nalm-6,
which has high efficiency for gene targeting.
PLoS ONE, 8, e61189 (2013)
6.
Horibata
K, Ukai A, Kimoto T, Suzuki T, Kamoshita N, Masumura K, Nohmi T and Honma M.
Evaluation of in vivo genotoxicity induced
by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the
Pig-a and gpt assays.
Environ. Mol. Mutagen., 54, 747-754 (2013)
2012年
原著論文
1.
Kanda GN, Togashi R, Harashima
H and Kamiya H.
Effects of endogenous proteins and microRNA target sequence in a
positive feedback system.
Biol. Pharm. Bull., 35, 1534-1538 (2012)
2.
Kamiya H and Kurokawa M.
Mutagenic bypass of 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) by
DNA polymerase κ in human cells.
Chem. Res. Toxicol., 25, 1771-1776 (2012)
3.
Fukunaga S, Kanda G, Tanase J,
Harashima H, Ohyama T and Kamiya H.
A designed curved DNA sequence remarkably enhances transgene
expression from plasmid DNA in mouse liver.
Gene Ther., 19, 828-835 (2012)
4.
Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M.
Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
J. Biol. Chem., 287, 21541-21549 (2012)
5.
Kawasaki K, Kanaba T, Yoneyama
M, Murata-Kamiya N, Kojima C, Ito Y, Kamiya H and Mishima M.
Insights into substrate recognition by the Escherichia coli Orf135 protein
through its solution structure.
Biochem. Biophys. Res. Commun., 420, 263-268 (2012)
6.
Kawasaki K, Yoneyama M,
Murata-Kamiya N, Harashima H, Kojima C, Ito Y, Kamiya H and Mishima M.
1H, 13C and 15N
NMR assignments of the Escherichia coli Orf135 protein.
Biomol. NMR Assign., 6, 1-4 (2012)
7.
Kanda G, Ochiai H, Harashima H
and Kamiya H.
CREB-binding protein transcription activation domain for enhanced
transgene expression by a positive feedback system.
J. Biotechnol., 157, 7-11 (2012)
2011年
原著論文
1.
Ochiai H, Harashima H and
Kamiya H.
Effects of insulator cHS4 on transgene expression from plasmid DNA
in a positive feedback system.
J. Biosci. Bioeng., 112, 432-434 (2011)
2.
Arimori T, Tamaoki H, Nakamura
T, Kamiya H, Ikemizu S, Takagi Y, Ishibashi T, Harashima H Sekiguchi M and Yamagata
Y.
Diverse substrate recognition and hydrolysis mechanisms of human
NUDT5.
Nucleic Acids Res., 39, 8972-8983 (2011)
3.
Morita Y, Tsuchiya H, Harashima
H and Kamiya H.
Correction of frameshift mutations with tailed duplex DNAs.
Biol. Pharm. Bull., 34, 1465-1468 (2011)
4.
Hori M, Suzuki T, Minakawa N,
Matsuda A, Harashima H and Kamiya H.
Mutagenicity of secondary oxidation products of
8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-hydroxy-2'-
deoxyguanosine 5'-triphosphate).
Mutat. Res., 714, 11-16 (2011)
5.
Suzuki T, Harashima H and Kamiya
H.
Unexpectedly weak impacts of decreased p53 and retinoblastoma
protein levels on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine).
Genes Environment, 33, 103-108 (2011)
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